Certificate in Downstream Processing

Description

This module aims to provide the student with a fundamental understanding of both the theory and practical aspects of protein purification processing as it pertains to the manufacture of modern biopharmaceutical products.

This course in NIBRT is designed to deliver an introduction to the typical downstream operations used in a biopharmaceutical production process. This course includes both hands-on practical and lecture components covering topics such as harvest, ultrafiltration/diafiltration, viral clearance and chromatography.

During this course, trainees will be introduced to the basics of filtration and chromatography in a theory session before building on this knowledge and performing these operations using a practical component.

Learning Outcomes

• Outline the main stages of downstream processing for biologics.
• Describe the main harvesting techniques used for purification of a biologic.
• Explain the basic theory and practice of column chromatography for biologic purification operations.
• Outline the theory and practice of ultrafiltration and diafiltration operations for biologics.

Credits

5 credits

Coursework

100%